Pause is the most frequent command I issue. Apart from the fact that it is virtually essential to taking screenshots, it makes controlling large fleets, keeping track of the 'health' of your ships, moving ships accurately, spotting enemies on the map early enough to send your forces to give them a warm welcome, telling damaged units to dock and a host of other commands doable. The computer (unless it has multiple CPU's) cannot multitask. It can only consider one ship at a time, issue one command at a time, etc. but it can interface with the game significantly faster than any human since a human has to keep moving the mouse to focus a different ship and press buttons on the keyboard to command them. Whereas the computer never needs to 'focus' a ship; it merely considers it, takes into account its range of vision and its current tactics and orders, and commands it from there. In a fraction of a microsecond (even if that is sometimes an 'improper' fraction.) Remember this one Rule Of Thumb: If in doubt, Pause. Then look, evaluate, decide. But do your thinking in paused mode!
Note: you cannot issue orders while in Pause, so if you want to issue commands: